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Effects of simulated high altitude hypoxia on the distribution of subgingival flora in rabbits with chronic periodontitis

Recently, researchers from the Department of Stomatology, Xinqiao Hospital, the Third Military Medical University published a paper to simulate the hypoxia environment at high altitude, build a rabbit periodontitis animal model, and study the difference between the main periodontal pathogens in subgingival plaque and the plain group It is pointed out that hypoxia environment at high altitude is the main reason for the aggravation of periodontitis. FN has a certain relationship with the aggravation of periodontitis at high altitude. this paper was published in the Journal of the Third Military…

Recently, researchers from the Department of Stomatology, Xinqiao Hospital, the Third Military Medical University published a paper to simulate the hypoxia environment at high altitude, build a rabbit periodontitis animal model, and study the difference between the main periodontal pathogens in subgingival plaque and the plain group It is pointed out that hypoxia environment at high altitude is the main reason for the aggravation of periodontitis. FN has a certain relationship with the aggravation of periodontitis at high altitude.

this paper was published in the Journal of the Third Military Medical University in 2012.

40 clean grade rabbits were randomly divided into four groups: plain experimental group, plain control group, plateau experimental group and plateau control group. The experimental group was ligated with orthodontic ligation wire and given a high sugar diet. The plateau group was set up in a low-pressure oxygen chamber with an altitude of 5 & nbsp; 000 & nbsp; m, hypoxia of 23 & nbsp; per day; h. After 8 weeks of continuous feeding, genomic DNA of subgingival plaque was extracted from

8 weeks later. Six kinds of periodontitis pathogens including Porphyromonas & nbsp; gingivalis (PG), Bacillus & nbsp; forsythus (BF) and Actinobacillus & nbsp; were detected by PCR amplification of 16S & nbsp; rDNA; The detection rates of actinomycetem comitans, AA, Prevotella & nbsp; intermedia, PI, Fusobacterium & nbsp; nucleus, FN and trepone Ma & nbsp; denticola, TD.

Compared with the plain experimental group, the gingival bleeding index, plaque index and periodontal pocket depth in the high altitude experimental group were significantly different (P & lt; 0.05). PG, BF, AA, PI, FN and TD were detected in the high altitude experimental group and the plain experimental group, and the detection rate of FN in the high altitude experimental group was 80% higher than that in the plain experimental group (P & LT); The detection rate of PI in plain experimental group was 70% higher than that in high altitude experimental group (P & lt; 0.05)

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